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5 results for "CFTR Blockers" in 产品
CFTR Blockers
The cystic fibrosis transmembrane conductance regulator (CFTR) is a 12-transmembrane ATP-binding cassette (ABC) transporter that functions as a cAMP-dependent chloride channel. It is localized to the apical membrane of epithelial cells within the lungs, liver, pancreas, digestive tract, reproductive tract and skin, where it is involved in fluid transport.
CFTR is composed of five domains: two membrane-spanning domains (MSD1, MSD2) that function as a chloride channel; two nucleotide-binding ...
Voltage-independent, selective CFTR chloride channel blocker
| Chemical Name: | 4-[[4-Oxo-2-thioxo-3-[3-trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]benzoic acid |
| Purity: | ≥98% |
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Kir6 (KATP) channel blocker
| Alternate Names: | Glyburide |
| Chemical Name: | 5-Chloro-N-[2-[4-[[[(Cylcohexylamino)carbonyl]amino]sulphonyl]phenyl]ethyl]-2-methoxybenzamide |
| Purity: | ≥98% |
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IKs blocker. Also blocks ICFTR
| Chemical Name: | trans-N-[6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide |
| Purity: | ≥98% |
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Mitochondrial hexokinase inhibitor
| Alternate Names: | AF 1890 |
| Chemical Name: | 1-[(2,4-Dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid |
| Purity: | ≥98% |
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Reversible, voltage-dependent CFTR chloride channel blocker
| Chemical Name: | N-2-Naphthalenyl-2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]glycine hydrazide |
| Purity: | ≥97% |
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