Chemical Name: N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)urea
Biological ActivityPQ 401 is an insulin-like growth factor receptor (IGF1R) inhibitor. Suppresses IGF-stimulated IGF-IR autophosphorylation with an IC50 value of 12 μM. Inhibits growth of MCF-7 breast cancer cells in vitro and in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Parallel synthesis of diarylureas and their evaluation as inhibitors of Ins-like growth factor receptor.
Anderson et al.
Citations for PQ 401
The citations listed below are publications that use Tocris products. Selected citations for PQ 401 include:
5 Citations: Showing 1 - 5
Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli.
Authors: Ilatovskaya Et al.
Am J Physiol Cell Physiol 2013;305:C1050
Ins-like growth factor (IGF) binding protein 2 functions coordinately with receptor protein tyrosine phosphatase β and the IGF-I receptor to regulate IGF-I-stimulated signaling.
Authors: Shen Et al.
Mol Cell Biol 2012;32:4116
Ins-like growth factor 1-mediated hyperthermia involves anterior hypothalamic Ins receptors.
Authors: Sanchez-Alavez Et al.
J Biol Chem 2011;286:14983
Activation of the Ins-like growth factor-1 receptor induces resistance to epidermal growth factor receptor antagonism in head and neck squamous carcinoma cells.
Authors: Jameson Et al.
Mol Cancer Ther 2011;10:2124
Ins-like growth factor-I-stimulated Ins receptor substrate-1 negatively regulates Src homology 2 domain-containing protein-tyrosine phosphatase substrate-1 function in vascular smooth muscle cells.
Authors: Radhakrishnan Et al.
J Biol Chem 2010;285:15682
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