PRIMA-1

Key Product Details

Product Description

PRIMA-1 is a selectively restores mutant p53 activity in tumor cells via activation of Bax and PUMA. Induces apoptosis and inhibits growth of tumors with mutant p53.

Product Specifications for PRIMA-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PRIMA-1

The following data is based on the product molecular weight 185.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.40 mL	26.99 mL	53.99 mL
5 mM	1.08 mL	5.40 mL	10.80 mL
10 mM	0.54 mL	2.70 mL	5.40 mL
50 mM	0.11 mL	0.54 mL	1.08 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 18 publications citing the usage of this product.

• Bykov Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database. Carcinogenesis 2002 PMID: 12507923
• Wang PRIMA-1 induces apoptosis by inhibiting JNK signalling but promoting the activation of Bax. Biochem.Biophys.Res.Commun. 2007 PMID: 17113036
• Bykov Restoration of the tumour suppressor function to mutant p53 by a low-molecular-weight compound. Nat.Med. 2002 PMID: 11875500

Product Documents for PRIMA-1