QWF

Tocris Bioscience | Catalog # 6642

MRGPRX2 antagonist; also NK1 receptor antagonist
Tocris Bioscience

Key Product Details

Description

MRGPRX2 antagonist; also NK1 receptor antagonist
View all Mas-Related G Protein Coupled Receptor Antagonists »

Product Description

QWF is a tripeptide substance P (SP) antagonist (IC50 = 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching in mice in vivo. QWF can be used in a small molecule cocktail to generate 3D culture of lung alveolar cells (see protocol below).

For more information about how QWF may be used, see our protocol: 3D Culture of Lung Alveolar Cells

Product Specifications for QWF

Molecular Weight

697.78

Formula

C38H43N5O8

Storage

Store at -20°C

Purity

≥90% (HPLC)

CAS Number

126088-82-2

PubChem ID

336446954

InChI Key

ZFZOHFAASQHWER-NCRUWMDKNA-N

SMILES

CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CC1=CN(C=O)C2=CC=CC=C12)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OCC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 10mg/ml in DMSO

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

Product Documents for QWF

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for QWF

For research use only

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