Ribociclib

Key Product Details

Product Description

Ribociclib is a dual cdk4/cdk6 inhibitor. Induces G₁ phase cell cycle arrest and senescence in neuroblastoma cell lines (IC₅₀ = 306 nM). Delays tumor growth in vivo. Orally bioavailable.

Product Specifications for Ribociclib

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Ribociclib

The following data is based on the product molecular weight 434.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.01 mL	115.06 mL	230.13 mL
0.5 mM	4.60 mL	23.01 mL	46.03 mL
1 mM	2.30 mL	11.51 mL	23.01 mL
5 mM	0.46 mL	2.30 mL	4.60 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Rader Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma. Clin. Cancer Res. 2013 PMID: 24045179

Product Documents for Ribociclib