RVG29-Cys New
Description: Nicotinic acetylcholine receptor targeting peptide for neuronal delivery
Purity: ≥95%
Biological Activity
RVG29-Cys is a peptide derived from rabies virus glycoprotein (RVG) able to specifically bind on the nicotinic acetylcholine receptors (nAchR) present on neuronal cells. RVG29-Cys can be used to functionalize LNPs via thiol-maleimide click chemistry for targeting nAchR present on blood-brain barrier (BBB). mRNA LNPs functionalized with RVG29-Cys shows improved transfection efficiency in cultured brain endothelial and neuronal cells, and in vivo, after systemic administration in mice.Technical Data
M.Wt:
3369.79
Formula:
C144H222N44O44S3
Sequence:
YTIWMPENPRPGTPCDIFTNSRGKRASNGC
Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
1404289-25-3
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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