(S)-(-)-Sulpiride

Tocris Bioscience | Catalog # 0895

Standard selective D2-like antagonist
Tocris Bioscience

Key Product Details

Description

Standard selective D2-like antagonist
View all Non-selective Dopamine Receptor Antagonists »

Product Description

(S)-(-)-Sulpiride is an active enantiomer. Selective D2-like dopamine antagonist (Ki values are ~ 0.015, ~ 0.013, 1, ~ 45 and ~ 77 μM at D2, D3, D4, D1 and D5 receptors respectively).

Racemate also available.

Product Specifications for (S)-(-)-Sulpiride

Molecular Weight

341.42

Formula

C15H23N3O4S

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

(S)-(-)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide

CAS Number

23672-07-3

PubChem ID

688272

InChI Key

BGRJTUBHPOOWDU-NSHDSACASA-N

SMILES

NS(C1=CC(C(NC[C@]2([H])CCCN2CC)=O)=C(OC)C=C1)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.14 100
Ethanol 3.41 10 with gentle warming

Preparing Stock Solutions for (S)-(-)-Sulpiride

The following data is based on the product molecular weight 341.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.93 mL 14.64 mL 29.29 mL
5 mM 0.59 mL 2.93 mL 5.86 mL
10 mM 0.29 mL 1.46 mL 2.93 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 80 publications citing the usage of this product.

Product Documents for (S)-(-)-Sulpiride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (S)-(-)-Sulpiride

For research use only

Citations for (S)-(-)-Sulpiride

Customer Reviews for (S)-(-)-Sulpiride (1)

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  • Selective block of dopamine receptors
    Name: Sergiy Sylantyev
    Species: Human
    Cell Line/Tissue: Stem cell - derived neurons
    Verified Customer | Posted 10/15/2020
    (S)‐sulpiride (Sul) was in use to block D2 dopamine receptors and thus prevent D2-mediated suppression of NMDA receptors response. The compound worked as expected, generating a discernible increase of amplitudes of NMDA-receptor – mediated evoked post-synaptic potentials in cultured dopamine neurons when applied with SCH‐23390 (see illustration). No problem with dissolution in DMSO for 10 mM stock.
    (S)-(-)-Sulpiride 0895

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