SB 225002

Tocris Bioscience | Catalog # 2725

Potent and selective CXCR2 antagonist
Tocris Bioscience

Key Product Details

Description

Potent and selective CXCR2 antagonist
View all Chemokine Receptor Antagonists »

Product Description

SB 225002 is a potent and selective CXCR2 chemokine receptor antagonist (IC50 = 22 nM) that displays > 150-fold selectivity over CXCR1 receptors. Causes inhibition of IL-8 and GROα-mediated calcium mobilization in HL60 cells (IC50 values are 8 and 10 nM respectively). Prevents IL-8-induced neutrophil chemotaxis in vitro and sequestration in vivo. Inhibits HIV replication in lymphocytes and macrophages.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Product Specifications for SB 225002

Molecular Weight

352.14

Formula

C13H10BrN3O4

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

N-(2-Bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)urea

CAS Number

182498-32-4

PubChem ID

3854666

InChI Key

MQBZVUNNWUIPMK-UHFFFAOYSA-N

SMILES

OC1=CC(=CC=C1NC(=O)NC1=CC=CC=C1Br)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.21 100
Ethanol 17.61 50

Preparing Stock Solutions for SB 225002

The following data is based on the product molecular weight 352.14.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.84 mL 14.20 mL 28.40 mL
5 mM 0.57 mL 2.84 mL 5.68 mL
10 mM 0.28 mL 1.42 mL 2.84 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

Calculators

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Product Documents for SB 225002

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SB 225002

For research use only

Customer Reviews for SB 225002 (2)

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  • Used for Migration assays
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: A549 or MDAMB231
    Verified Customer | Posted 07/01/2020
    We ordered this product, combining with another inhibitor, to confirm the migration.To confirm that tested product induces migration, we also screen all MAPK inhibitors and MIF receptor antagonists
    Receptor antagonists (SB225002: for CXCR2, AMD3465: for CXCR4, RS504393: for CCR2 and Maraviroc: for CCR5) at 10 μM
    SB 225002 2725
  • SB 225002
    Name: Anonymous
    Verified Customer | Posted 08/22/2016

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