SCH 529074

Key Product Details

Product Description

SCH 529074 is a restores mutant p53 activity. Binds p53 DNA binding domain (K_d = 1-2 μM) and restores wild-type function to many oncogenic mutants by acting as a chaperone. Inhibits ubiquitination of p53 by HDM2. Triggers apoptosis in tumor cell lines and reduces tumor growth in a xenograft model.

Product Specifications for SCH 529074

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SCH 529074

The following data is based on the product molecular weight 563.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.77 mL	8.87 mL	17.74 mL
5 mM	0.35 mL	1.77 mL	3.55 mL
10 mM	0.18 mL	0.89 mL	1.77 mL
50 mM	0.04 mL	0.18 mL	0.35 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Essmann & Schulze-Osthoff Translational approaches targeting the p53 pathway for anti-cancer therapy. Br.J.Pharmacol. 2012 PMID: 21718309
• Demma SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53. J.Biol.Chem. 2010 PMID: 20124408

Product Documents for SCH 529074