ShK-Dap22

Tocris Bioscience | Catalog # 3220

Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro
Tocris Bioscience
Discontinued Product
3220 has been discontinued. View all Voltage-gated Potassium Channel Blockers products.

Key Product Details

Description

Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro
View all Voltage-gated Potassium Channel Blockers »

Product Description

ShK-Dap22 is an extremely potent KV1.3 channel blocker (Kd = 23 pM for mKV1.3 currents). Selective for KV1.3 over other mammalian potassium channels (IC50 values are 23, 1800, 10500, 37000 and 39000 pM for mKV1.3, mKV1.1, hKV1.6, mKV1.4 and rKV1.2 respectively, and >100000 pM for hKV1.5, mKV1.7, hKV3.1, rKV3.4 and hKCa4). Suppresses T cell activation in vitro (IC50 < 500 pM).

Product Specifications for ShK-Dap22

Molecular Weight

4012.70

Formula

C166H268N54O48S7

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

220384-25-8

PubChem ID

122187345

InChI Key

PFWOJTLVNOZSGQ-RIMJLNMDSA-N

SMILES

[H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@H](CN)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC=N4)NC(=O)[C@H](CCCCN)NC3=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC1=O)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in water

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Background References

References are publications that support the biological activity of the product.

Product Documents for ShK-Dap22

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ShK-Dap22

For research use only

Customer Reviews for ShK-Dap22 (1)

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  • Great product with reproducible data
    Name: Sadequl Islam
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/22/2018
    This compound was used in our cell culture lab to quantify blocking activity of Kv channels. It produced reproducible data in osteosarcoma cell line. Great product, hugely recommend.
    ShK-Dap22 3220

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