21 results for "Voltage-gated Potassium Channel Blockers" in 产品
Voltage-gated Potassium Channel Blockers
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming α-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.
Blocker of KV1.5 channel and IKur current
| Alternate Names: | Diphenyl phosphine oxide-1 |
| Chemical Name: | [1S-(1α,2α,5β)]-[5-Methyl-2-(1-methylethyl)cyclohexyl]diphenylphosphine oxide |
| Purity: | ≥98% |
KV7 (KCNQ) channel blocker
| Alternate Names: | DuP 996 |
| Chemical Name: | 1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one dihydrochloride |
| Purity: | ≥98% |
Cell-permeable Ca2+ chelator
| Chemical Name: | 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl ester) |
| Purity: | ≥95% |
Non-selective KV channel blocker
| Alternate Names: | 4-AP |
| Purity: | ≥98% |
CaM kinase II inhibitor; also K+ channel blocker (KV)
| Chemical Name: | N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulphonamide |
| Purity: | ≥98% |
KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)
| Chemical Name: | N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride |
| Purity: | ≥98% |
H1 antagonist. Also KV11.1 (hERG) and Kir6 (KATP) channel blocker
| Chemical Name: | α-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol |
| Purity: | ≥98% |
Potent Kv2.1 and Kv2.2 channel blocker
| Purity: | ≥95% |
IKs blocker. Also blocks ICFTR
| Chemical Name: | trans-N-[6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide |
| Purity: | ≥98% |
IKs blocker. Enantiomer of Chromanol 293B (Cat. No. 1412)
| Chemical Name: | N-[(3R,4S)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methylethanesulfonamide |
| Purity: | ≥98% |
Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents
| Chemical Name: | 10,10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride |
| Purity: | ≥98% |
Blocker of KV1.3 and KV1.4 channels
| Chemical Name: | 4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidine hydrochloride |
| Purity: | ≥98% |
KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)
| Alternate Names: | Tikosyn,UK 68798 |
| Chemical Name: | 1-(4-Methanesulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino]ethane |
| Purity: | ≥98% |
HIF-PH inhibitor; erythropoietic
| Alternate Names: | FG 4592 |
| Chemical Name: | N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine |
| Purity: | ≥98% |
Orally active, potent H1 antagonist; also KV11.1 (hERG) channel blocker
| Alternate Names: | Hismanal |
| Chemical Name: | 1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine |
| Purity: | ≥98% |
Potent and selective IKs blocker
| Chemical Name: | 2-(4-Chlorophenoxy)-2-methyl-N-[5-[(methylsulfonyl)amino]tricyclo[3.3.1.13,7]dec-2-yl]-propanamide |
| Purity: | ≥98% |
Inactive analog of KN 93. K+ channel (Kv) blocker
| Chemical Name: | 2-[N-(4'-Methoxybenzenesulfonyl)]amino-N-(4'-chlorophenyl)-2-propenyl-N-methylbenzylamine phosphate |
| Purity: | ≥98% |
Potent KV1.3 channel blocker
| Chemical Name: | 4-(4-Phenylbutoxy)-7H-furo[3,2-g][1]benzopyran-7-one |
| Purity: | ≥98% |
Potent and selective Iks channel blocker
| Chemical Name: | N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide |
| Purity: | ≥98% |
Potent and selective KV7.2 inhibitor; brain penetrant
| Chemical Name: | (S)-2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide |
| Purity: | ≥98% |
Kv11.1 (hERG) channel blocker
| Chemical Name: | 1-[[[5-(4-Chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione dihydrochloride |
| Purity: | ≥97% |
