SHP-2/PTPN11 Antibody (255509) [HRP]

Name: SHP-2/PTPN11 Antibody (255509) [HRP]
Brand: Novus Biologicals
SKU: FAB1894H
Price: 569 USD
Availability: InStock

Novus Biologicals | Catalog # FAB1894H

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Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Knockout Validated, Western Blot

Label

HRP

Antibody Source

Monoclonal Rat IgG_2B Clone # 255509

View all SHP-2 Primary Antibodies »

Product Specifications

Immunogen

E. coli-derived recombinant human SHP-2
Thr2-Arg593
Accession # NP_002825

Specificity

Detects human, mouse, and rat SHP-2 in Western blots. In Western blots, no cross-reactivity with recombinant human SHP-1 is observed.

Clonality

Monoclonal

Host

Rat

Isotype

IgG_2B

Applications for SHP-2/PTPN11 Antibody (255509) [HRP]

Application

Recommended Usage

Knockout Validated

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

PBS

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: SHP-2

SHP-2 (also called PTP2C, SH-PTP2, PTP1D, SH-PTP3, Syp and PTPN11) is a protein tyrosine phosphatase (PTP) expressed in most cell types (unlike SHP-1), (1). SHP-2 is involved in t the signal transduction stimulated by EGF, PDGF and Insulin. After cell stimulation, SHP-2 (as well as SHP-1), translocates from cytosol to the plasma membrane and binds to tyrosine-phosphorylated receptors through their SH2 domains, becoming activated in the process (2). When phosphorylated, SHP-2 has been shown to bind Grb2, EGFR, PDGFR, IRS-1 via its SH2 domain (3). Over expression of SHP-2 leads to Juvenile Myelo-monocytic Leukemia and Noonan syndrome (4-5).

Long Name

Src Homology Region 2 Domain Phosphatase 2

Alternate Names

PTP1D, PTP2C, PTPN11, SH-PTP2, SHP2

Gene Symbol

PTPN11

Additional SHP-2 Products

Product Documents for SHP-2/PTPN11 Antibody (255509) [HRP]

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Product Specific Notices for SHP-2/PTPN11 Antibody (255509) [HRP]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.