CTLA-4/CD152 (Cytotoxic T-Lymphocyte Antigen 4) is a transmembrane T cell inhibitory molecule that is expressed as a covalent homodimer. CTLA-4 is recruited from intracellular vesicles to the immunological synapse beginning 1-2 days after T cell activation. It forms a linear lattice with B7-1 on APC, inducing negative regulatory signals and ending CD28-dependent T cell activation. Mice deleted for CTLA-4 develop lethal autoimmune reactions due to continued T cell activation and poor control by regulatory T cells which constitutively express CTLA-4.
Simple Plex Control for Human CTLA-4
R&D Systems | Catalog # 898485
Control for use with Human and Non-Human Primate CTLA-4 Simple Plex Cartridge Kit
Loading...
Key Product Details
Species
Human, Non-human Primate
Applications
Control, Simple Plex Automated Immunoassay
Product Summary for Simple Plex Control for Human CTLA-4
INTENDED USE AND DESCRIPTION: For use a quantitative control for the determination of human and NHP CTLA-4 concentrations in biological fluids. Controls are supplied lyophilized. Please refer to the lot specific certificate of analysis and Simple Plex Lyophilized Quality Control product insert for additional information.
Loading...
Formulation, Preparation, and Storage
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
• Store lyophilized controls at 2-8 °C. Lyophilized controls are stable for up to 12 months from date of receipt.
• Reconstituted controls are stable for up to 6 months from date of preparation when stored at ≤ -70 °C. Storage at -20° C is not recommended.
• Individual frozen aliquots of low and high controls are designed as single-use entities. Thaw directly before use and discard any remaining volume.
• Reconstituted controls are stable for up to 6 months from date of preparation when stored at ≤ -70 °C. Storage at -20° C is not recommended.
• Individual frozen aliquots of low and high controls are designed as single-use entities. Thaw directly before use and discard any remaining volume.
Background: CTLA-4
Long Name
Cytotoxic T-lymphocyte-associated Molecule 4
Alternate Names
CD152, CTLA4
Gene Symbol
CTLA4
Additional CTLA-4 Products
Product Documents for Simple Plex Control for Human CTLA-4
Product Specific Notices for Simple Plex Control for Human CTLA-4
For research use only
Citations for Simple Plex Control for Human CTLA-4
View all citations for the Simple Plex platform on Bio-Techne.com.
Please visit our Instrument Citation Database on Bio-Techne.com to search our collection of scientific articles that feature our instruments.
Powered by Bioz
Customer Reviews for Simple Plex Control for Human CTLA-4
There are currently no reviews for this product. Be the first to review Simple Plex Control for Human CTLA-4 and earn rewards!
Have you used Simple Plex Control for Human CTLA-4?
Submit a review and receive an Amazon gift card!
$25/€18/£15/$25CAN/¥2500 Yen for a review with an image
$10/€7/£6/$10CAN/¥1110 Yen for a review without an image
Submit a review