CTLA-4/CD152 (Cytotoxic T-Lymphocyte Antigen 4) is a transmembrane T cell inhibitory molecule that is expressed as a covalent homodimer. CTLA-4 is recruited from intracellular vesicles to the immunological synapse beginning 1-2 days after T cell activation. It forms a linear lattice with B7-1 on APC, inducing negative regulatory signals and ending CD28-dependent T cell activation. Mice deleted for CTLA-4 develop lethal autoimmune reactions due to continued T cell activation and poor control by regulatory T cells which constitutively express CTLA-4.
Simple Plex Control for Human CTLA-4
R&D Systems | Catalog # 898485
Control for use with Human and Non-Human Primate CTLA-4 Simple Plex Cartridge Kit
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Key Product Details
Species
Human, Non-human Primate
Applications
Control, Simple Plex Automated Immunoassay
Product Summary for Simple Plex Control for Human CTLA-4
INTENDED USE AND DESCRIPTION: For use a quantitative control for the determination of human and NHP CTLA-4 concentrations in biological fluids. Controls are supplied lyophilized. Please refer to the lot specific certificate of analysis and Simple Plex Lyophilized Quality Control product insert for additional information.
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Formulation, Preparation, and Storage
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
• Store lyophilized controls at 2-8 °C. Lyophilized controls are stable for up to 12 months from date of receipt.
• Reconstituted controls are stable for up to 6 months from date of preparation when stored at ≤ -70 °C. Storage at -20° C is not recommended.
• Individual frozen aliquots of low and high controls are designed as single-use entities. Thaw directly before use and discard any remaining volume.
• Reconstituted controls are stable for up to 6 months from date of preparation when stored at ≤ -70 °C. Storage at -20° C is not recommended.
• Individual frozen aliquots of low and high controls are designed as single-use entities. Thaw directly before use and discard any remaining volume.
Background: CTLA-4
Long Name
Cytotoxic T-lymphocyte-associated Molecule 4
Alternate Names
CD152, CTLA4
Gene Symbol
CTLA4
Additional CTLA-4 Products
Product Documents for Simple Plex Control for Human CTLA-4
Certificate of Analysis
To download a Certificate of Analysis, please enter your Simple Plex catalog number and lot number in the search boxes below.
Product Specific Notices for Simple Plex Control for Human CTLA-4
For research use only
Citations for Simple Plex Control for Human CTLA-4
View all citations for the Simple Plex platform on Bio-Techne.com.
Please visit our Instrument Citation Database on Bio-Techne.com to search our collection of scientific articles that feature our instruments.
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