SKF 91488 dihydrochloride
Chemical Name: 4-(N,N-Dimethylamino)butylisothiourea dihydrochloride
Biological Activity
SKF 91488 dihydrochloride is a homolog of dimaprit (Cat. No. 0506); strong inhibitor of histamine N-methyltransferase. Exhibits no histamine agonist activity.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Effects of two histamine-N-methyltransferase inhibitors, SKF 91488 and BW 301U, in rodent antinociception.
Aiello et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1997;355:354 -
New inhibitors of histamine N-methyl-transferase.
Beaven and Shaff
Biochem.Pharmacol., 1979;28:183 -
Inhibition of histamine methylation in vivo by the dimaprit analog SKF compound 91488.
Beaven and Shaff
Agents Actions, 1979;9:455 -
Histamine N-methyl transferase controls the contractile response of guinea pig trachea to histamine.
Ohuri et al.
J.Pharmacol.Exp.Ther., 1992;261:1268
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