SMER 28

Tocris Bioscience | Catalog # 4297

Positive regulator of autophagy
Tocris Bioscience

Key Product Details

Description

Positive regulator of autophagy
View all Autophagy-related Compounds »

Product Description

SMER 28 is a positive regulator of autophagy in a mechanism independent from the mTOR pathway. Increases autophagosome synthesis and enhances clearance of model autophagy substrates such as mutant huntingtin and A53T α-synuclein, associated with Huntington's and Parkinson's diseases, respectively. Promotes reprogramming of fibroblasts to neural stem-like cells in combination with other chemical reagents.

Product Specifications for SMER 28

Molecular Weight

264.12

Formula

C11H10BrN3

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

6-Bromo-N-2-propenyl-4-quinazolinamine

CAS Number

307538-42-7

PubChem ID

1560402

InChI Key

BCPOLXUSCUFDGE-UHFFFAOYSA-N

SMILES

C=CCNC2=NC=NC1=CC=C(Br)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.41 100

Preparing Stock Solutions for SMER 28

The following data is based on the product molecular weight 264.12.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.79 mL 18.93 mL 37.86 mL
5 mM 0.76 mL 3.79 mL 7.57 mL
10 mM 0.38 mL 1.89 mL 3.79 mL
50 mM 0.08 mL 0.38 mL 0.76 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

Product Documents for SMER 28

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SMER 28

For research use only

Related Research Areas

Autophagy

Customer Reviews for SMER 28 (1)

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  • Works good
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Neural Stem Cells
    Verified Customer | Posted 06/25/2020
    M9 medium (10 µM SMER28)
    SMER 28 4297

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