SMER 3

Key Product Details

Product Description

SMER 3 is a selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCF^Met30) in vitro and in vivo. Induces the expression of MET genes; blocks cell proliferation. Enhancer of rapamycin (Cat. No. 1292).

Product Specifications for SMER 3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SMER 3

The following data is based on the product molecular weight 224.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	5.95 mL	29.74 mL	59.48 mL
3.75 mM	1.19 mL	5.95 mL	11.90 mL
7.5 mM	0.59 mL	2.97 mL	5.95 mL
37.5 mM	0.12 mL	0.59 mL	1.19 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

• Aghajanyy Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor. Nat.Biotechnol. 2010 PMID: 20581845

Product Documents for SMER 3