SR 95531 hydrobromide

Tocris Bioscience | Catalog # 1262

Competitive and selective GABAA antagonist
Tocris Bioscience

Key Product Details

Description

Competitive and selective GABAA antagonist

Alternative Names

Gabazine
View all GABA-A Receptor Antagonists »

Product Description

SR 95531 hydrobromide is a selective, competitive GABAA receptor antagonist and allosteric inhibitor (IC50 = 200 nM). SR 95531 displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM. Unlike Bicuculline (Cat. No. 0130), SR 95531 selectively antagonizes GABA-induced Cl- currents with little action on Pentobarbitone-induced currents (Cat. No. 4579). SR 95531 can act as an agonist at high concentrations (>100 μM) and is a weak agonist at GABAA receptors with α1β2(Y157S)γ2L subunits. SR 95531 also acts as a competitive antagonist of recombinant glycine receptors and exhibits greater potency at glycine receptors containing β subunits.

Product Specifications for SR 95531 hydrobromide

Molecular Weight

368.23

Formula

C15H17N3O3.HBr

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

6-Imino-3-(4-methoxyphenyl)-1(6H)-pyridazinebutanoic acid hydrobromide

CAS Number

104104-50-9

PubChem ID

107895

InChI Key

GFZHNFOGCMEYTA-UHFFFAOYSA-N

SMILES

Br.COC1=CC=C(C=C1)C1=NN(CCCC(O)=O)C(=N)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 9.21 25
DMSO 36.82 100

Preparing Stock Solutions for SR 95531 hydrobromide

The following data is based on the product molecular weight 368.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.72 mL 13.58 mL 27.16 mL
5 mM 0.54 mL 2.72 mL 5.43 mL
10 mM 0.27 mL 1.36 mL 2.72 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Documents for SR 95531 hydrobromide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SR 95531 hydrobromide

For research use only

Related Research Areas

GABA Receptors

Citations for SR 95531 hydrobromide

Customer Reviews for SR 95531 hydrobromide (1)

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  • SR95531 for slice electrophysiology
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    Verified Customer | Posted 01/08/2018
    I use this at a concentration of 10 uM in my aCSF bath.
    I use SR95531 to block GABAA channels when performing slice electrophysiology.

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