STING Degrader SP23

Key Product Details

Product Description

STING Degrader SP23 is a selective stimulator of interferon gene (STING) Degrader (PROTAC^®; DC₅₀ = 3.2 μM). Comprises the STING inhibitor (C-170), joined by a linker to a CRBN ligand Pomalidomide (Cat. No. 6302). It does not degrade JAK2, STAT3, PI 3-K, AKT and TLR4 in THP-1 cells. STING Degrader SP23 dose dependently reduces the levels of IFN-β, IL-6, and CXCL10 triggered by cGAMP in THP-1 cells; it also modulates the downstream signals of the STING signaling pathway in vivo. STING Degrader SP23 has high anti-inflammatory efficacy in a cisplatin-induced acute kidney injury mouse model.

Negative control STING Degrader N-Me-SP23 (Cat. No. 8054) and STING/TMEM173 antibodies validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF6516 and NBP3-18816.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Product Specifications for STING Degrader SP23

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for STING Degrader SP23

The following data is based on the product molecular weight 699.68.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.43 mL	7.15 mL	14.29 mL
5 mM	0.29 mL	1.43 mL	2.86 mL
10 mM	0.14 mL	0.71 mL	1.43 mL
50 mM	0.03 mL	0.14 mL	0.29 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Liu Novel CRBN-recruiting proteolysis-targeting chimeras as degraders of stimulator of interferon genes with in vivo anti- inflammatory efficacy. J.Med.Chem. 2022 PMID: 35452223

Product Documents for STING Degrader SP23