STK38 Antibody

Novus Biologicals | Catalog # NBP2-27552

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human, Rat

Predicted:

Bovine (100%), Canine (100%), Porcine (100%). Backed by our 100% Guarantee.

Applications

Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
View all NDR1/STK38 Primary Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-KPTVATSNHPET corresponding to C-Terminus (near) according to NP_009202.1.

Specificity

This antibody is NOT expected to cross-react with STK38L (GeneID 23012).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for STK38 Antibody

Western Blot: STK38 Antibody [NBP2-27552]

Western Blot: STK38 Antibody [NBP2-27552]

Western Blot: STK38 Antibody [NBP2-27552] - NBP2-27552 (0.5ug/ml) staining of Human Spleen lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for STK38 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:32000

Western Blot

0.5 - 2 ug/ml
Application Notes
WB: Approx. 55 kDa band observed in human and rat spleen lysates (calculated MW of 54.2 kDa band according to NP_009202.1).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: NDR1/STK38

STK38 belongs to the NDR family of serine/threonine protein kinases. NDR kinases require the phosphorylation of conserved Ser/Thr residues for activation. NDR family members have two unique stretches of primary sequence: an N-terminal regulatory (NTR) domain and an insert of several residues between subdomains VII and VIII of the kinase domain. The kinase domain insert functions as an auto-inhibitory sequence (AIS), while binding of the co-activator MOB (Mps-one binder) proteins to the NTR domain releases NDR kinases from inhibition of autophosphorylation. STK38 negatively regulates the activation of MEKK1/2 by direct interaction with the catalytic domain of MEKK1/2. The negative regulation of MEKK1/2 is not due to its phosphorylation by STK38.

Long Name

Nuclear Dbf2-related Kinase 1

Alternate Names

STK38

Entrez Gene IDs

361813 (Rat)

Gene Symbol

STK38

UniProt

NP_009202.1 (Human)

Additional NDR1/STK38 Products

Product Documents for STK38 Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for STK38 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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