TAT-Gap19

Name: TAT-Gap19
Brand: Tocris Bioscience
SKU: 6227
Price: 330 USD
Availability: InStock

Tocris Bioscience | Catalog # 6227

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Citations (10)

Product Documents

Cx43 hemichannel blocker

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Cx43 hemichannel blocker

View all Gap Channel Blockers »

Product Description

TAT-Gap19 is a Cx43 hemichannel blocker (IC₅₀ ~7 μM). No significant affinity for gap junctions or Panx1 channels. N-terminal transactivator of transcription (TAT) motif promotes membrane permeability and increases inhibitory effect of Gap19 (Cat. No. 5353). Active in vivo. Brain penetrant.

Product Specifications for TAT-Gap19

Molecular Weight

2703.28

Formula

C₁₁₉H₂₁₂N₄₆O₂₆

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

1507930-54-2

PubChem ID

127021051

InChI Key

ALNCFPIRTLVJPY-XELKYWHDNA-N

SMILES

[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

音量

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Desired Reconstitution Concentration

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

Freitas-Andrade and Naus Astrocytes in neuroprotection and neurodegeneration: The role of connexin43 and pannexin1. Neuroscience. 2016 PMID: 25913636
Abudara The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes. Front.Cell.Neurosci. 2014 PMID: 25374505

Product Documents for TAT-Gap19

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for TAT-Gap19

For research use only

Related Research Areas

Ion Channels and Regulators

Citations for TAT-Gap19

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