TBK1 PROTAC® 3i

Tocris Bioscience | Catalog # 7259

Potent TANK-binding kinase 1 (TBK1) PROTAC®
Tocris Bioscience

Key Product Details

Description

Potent TANK-binding kinase 1 (TBK1) PROTAC®
View all Active Degraders »

Product Description

TBK1 PROTAC® 3i is a potent TANK-binding kinase 1 (TBK1) PROTAC® Degrader (DC50 = 12 nM, Dmax = 96%). Exhibits >50-fold selectivity for TBK1 over the closely related IKKε. Comprises a ligand for von-Hippel Lindau (VHL) protein joined by a linker to a TBK1-targeting moiety. Brings about near complete degradation of TBK1 in mutant K-Ras and wild-type cancer cell lines with no significant effect of proliferation.

Negative control TBK1 control PROTAC® 4 (Cat. No. 7260) and TBK1 antibodies validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF9934 and NB100-56705.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Product Specifications for TBK1 PROTAC® 3i

Molecular Weight

1093.19

Formula

C53H74BrN9O9S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2S,4R)-1-((S)-18-(4-((5-Bromo-4-((3-(N-methylcyclobutanecarboxamido)propyl)amino)pyrimidin-2-yl)amino)phenoxy)-2-(tert-butyl)-4-oxo-6,10,15-trioxa-3-azaoctadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

CAS Number

2052306-13-3

PubChem ID

124108661

InChI Key

QMGHHBHPDDAGGO-IIWOMYBWSA-N

SMILES

CN(C(C1CCC1)=O)CCCNC2=NC(NC3=CC=C(C=C3)OCCCOCCCCOCCCOCC(N[C@@H](C(C)(C)C)C(N4C[C@@H](C[C@H]4C(NCC5=CC=C(C6=C(N=CS6)C)C=C5)=O)O)=O)=O)=NC=C2Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 109.32 100

Preparing Stock Solutions for TBK1 PROTAC® 3i

The following data is based on the product molecular weight 1093.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.91 mL 4.57 mL 9.15 mL
5 mM 0.18 mL 0.91 mL 1.83 mL
10 mM 0.09 mL 0.46 mL 0.91 mL
50 mM 0.02 mL 0.09 mL 0.18 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for TBK1 PROTAC® 3i

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TBK1 PROTAC® 3i

For research use only

Citations for TBK1 PROTAC® 3i

Customer Reviews for TBK1 PROTAC® 3i

There are currently no reviews for this product. Be the first to review TBK1 PROTAC® 3i and earn rewards!

Have you used TBK1 PROTAC® 3i?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card