Temsirolimus

Tocris Bioscience | Catalog # 5264

mTOR inhibitor; antitumor
Tocris Bioscience

Key Product Details

Description

mTOR inhibitor; antitumor

Alternative Names

CCI-779
View all mTOR Inhibitors »

Product Description

Temsirolimus is a mTOR inhibitor; inhibits tumor growth in breast cancer cell lines (IC50 values are 1.6 and 4.3 nM for SKBr3 and BT474, respectively). Inhibits HIF-1α-mediated VEGF production in breast cancer cell lines (BT474 and MDA-MB-231). Directly inhibits serum and VEGF mediated endothelial cell proliferation and morphogenesis in vitro and vessel formation in vivo. Causes G1/S cell cycle arrest in multiple cancer cell lines. Antiangiogenic. Activates autophagy.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for Temsirolimus

Molecular Weight

1030.29

Formula

C56H87NO16

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

Rapamycin 42-[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate]

CAS Number

162635-04-3

PubChem ID

6918289

InChI Key

CBPNZQVSJQDFBE-FUXHJELOSA-N

SMILES

O=C([C@H](C)\C=C([C@@H](O)[C@@H](OC)C([C@@H]4C)=O)/C)C[C@]([C@H](C)C[C@H]2C[C@@H](OC)[C@H](OC(C(CO)(C)CO)=O)CC2)([H])OC([C@@]1([H])N(C(C([C@@]3(O)[C@H](C)CC[C@](C[C@@H](/C(C)=C/C=C/C=C/[C@H](C4)C)OC)([H])O3)=O)=O)CCCC1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 103.03 100
Ethanol 103.03 100

Preparing Stock Solutions for Temsirolimus

The following data is based on the product molecular weight 1030.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.97 mL 4.85 mL 9.71 mL
5 mM 0.19 mL 0.97 mL 1.94 mL
10 mM 0.10 mL 0.49 mL 0.97 mL
50 mM 0.02 mL 0.10 mL 0.19 mL

Calculators

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Product Documents for Temsirolimus

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Temsirolimus

For research use only

Related Research Areas

Autophagy

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  • Temsirolimus abolishes aversion induced by kappa opioid receptor agonists
    Name: Luca Zangrandi
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 08/13/2021
    Conditioned place aversion. Systemic administration

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