Tertiapin-Q

Tocris Bioscience | Catalog # 1316

Selective blocker of inward-rectifier K+ channels
Tocris Bioscience

Key Product Details

Description

Selective blocker of inward-rectifier K+ channels
View all Inward Rectifier Potassium Channel Blockers »

Product Description

Tertiapin-Q is a high affinity blocker for inward-rectifier K+ channels. Tertiapin-Q is a stable derivative of the bee venom toxin tertiapin. Tertiapin-Q binds to ROMK1 (Kir1.1) and GIRK1/4 (Kir3.1/3.4) channels with high affinity (Ki values are 1.3 and 13.3 nM respectively) and is selective over Kir2.1 channels. Tertiapin-Q improves heart rate and atrioventricular conduction in a mouse model of bradycardia. Derivative Tertiapin LQ (Cat. No. 4339) also available.

Licensing Information

Sold under license granted by the University of Pennsylvania

Product Specifications for Tertiapin-Q

Molecular Weight

2452.00

Formula

C106H175N35O24S4

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

910044-56-3

PubChem ID

90479782

InChI Key

GMZAXHIZSCRCHM-MIPBWYARSA-N

SMILES

[H]N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC3=CNC=N3)NC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC3=CNC4=C3C=CC=C4)NC2=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 2mg/ml in water

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 76 publications citing the usage of this product.

Product Documents for Tertiapin-Q

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Tertiapin-Q

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for Tertiapin-Q (2)

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2 Customer Ratings
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  • Works as expected.
    Name: Anonymous
    Species: Mouse
    Cell Line/Tissue: Bed nucleus of the stria terminalis
    Verified Customer | Posted 05/26/2020
    We performed ex-vivo slice physiology and pre-incubated the slices in tertiapin-Q (200 nM). Pre-incubation blocked inward rectifying channels.
    Tertiapin-Q 1316
  • Tertiapin-Q is a very potent Kir channel blocker even at low concentrations
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/31/2018
    The product shows great Kir channel blocking properties even at very small cocentrations, the data was reproducible every time.
    Tertiapin-Q 1316

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