Thalidomide-4-hydroxyacetate

Tocris Bioscience | Catalog # 6466

Carboxylic acid-functionalized Thalidomide; cereblon ligand for PROTACs
Tocris Bioscience

Key Product Details

Description

Carboxylic acid-functionalized Thalidomide; cereblon ligand for PROTACs
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Product Description

Thalidomide-4-hydroxyacetate is a derivative of Thalidomide (Cat.No. 0652), commonly used as a precursor to PROTAC® that hijacks cereblon as the E3 ubiquitin ligase component. Supplied with a carboxylic acid functional handle at a position known not to significantly affect binding to cereblon, for ready conjugation to a linker/target protein ligand.

Thalidomide-4-hydroxyacetate has been recently renamed. The previous name for this product was TC E3 5031.

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PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Require a different derivative? Get in touch.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Product Specifications for Thalidomide-4-hydroxyacetate

Molecular Weight

332.26

Formula

C15H12N2O7

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetic acid

CAS Number

1061605-21-7

PubChem ID

25015436

InChI Key

ZVWIXIGBWIEDFO-UHFFFAOYSA-N

SMILES

O=C(N1C(CC2)C(NC2=O)=O)C3=C(C1=O)C(OCC(O)=O)=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product.

Product Documents for Thalidomide-4-hydroxyacetate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Thalidomide-4-hydroxyacetate

For research use only

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