Thalidomide, 5'-fluoro

Tocris Bioscience | Catalog # 7456

Fluoro functionalized Thalidomide; cereblon ligand for PROTACs
Tocris Bioscience

Key Product Details

Description

Fluoro functionalized Thalidomide; cereblon ligand for PROTACs
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Product Description

Thalidomide 5'- fluoro is a derivative of Thalidomide (Cat. No. 0652), commonly used as a precursor to PROTAC® Degraders that hijacks cereblon as the E3 ubiquitin ligase component. Supplied with a fluoro functional handle at a position known not to significantly affect binding to cereblon, ready for conjugation to a linker/target protein ligand.

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PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

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Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Product Specifications for Thalidomide, 5'-fluoro

Molecular Weight

276.22

Formula

C13H9FN2O4

Storage

Store at +4°C

Purity

≥95%

Chemical Name

2-(2,6-Dioxo-3-piperidinyl)-5-fluoro-1H-isoindole-1,3(2H)-dione

CAS Number

835616-61-0

PubChem ID

70876201

InChI Key

MPQLCQKBYRSPNA-UHFFFAOYSA-N

SMILES

FC1=CC=C2C(N(C(C2=C1)=O)C3CCC(NC3=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product.

Product Documents for Thalidomide, 5'-fluoro

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Thalidomide, 5'-fluoro

For research use only

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