Thalidomide, propargyl

Tocris Bioscience | Catalog # 6685

Alkyne-functionalized Thalidomide; 'click' cereblon ligand for PROTACs
Tocris Bioscience

Key Product Details

Description

Alkyne-functionalized Thalidomide; 'click' cereblon ligand for PROTACs
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Product Description

Thalidomide, propargyl is a click-activated Thalidomide (Cat.No. 0652); can be used as a precursor to a PROTAC® that hijacks cereblon as the E3 ubiquitin ligase component. Supplied with an alkyne functional handle at a position known not to significantly affect binding to cereblon, for ready click conjugation to a linker/target protein ligand.

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PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Require a different derivative? Get in touch.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Product Specifications for Thalidomide, propargyl

Molecular Weight

312.28

Formula

C16H12N2O5

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

2-(2,6-Dioxo-3-piperidinyl)-4-(2-propyn-1-yloxy)-1H-isoindole-1,3(2H)-dione

CAS Number

2098487-39-7

PubChem ID

132118478

InChI Key

NOGQTNDSZFYNTM-UHFFFAOYSA-N

SMILES

O=C1N(C(C2=C(C=CC=C12)OCC#C)=O)C3CCC(NC3=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product.

Product Documents for Thalidomide, propargyl

Certificate of Analysis

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Product Specific Notices for Thalidomide, propargyl

For research use only

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