THIQ

Tocris Bioscience | Catalog # 3032

Potent and selective MC4 receptor agonist
Tocris Bioscience

Key Product Details

Description

Potent and selective MC4 receptor agonist
View all Melanocortin Receptor Agonists »

Product Description

THIQ is a potent and selective melanocortin 4 (MC4) receptor agonist (IC50 values are 1.2, 761 and 2067 nM for human MC4, MC3 and MC1 receptors respectively). Enhances intracavernosal pressure and stimulates erectile activity in rats ex copula following systemic administration.

Product Specifications for THIQ

Molecular Weight

589.17

Formula

C33H41ClN6O2

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

N-[(1R)-1-[(4-Chlorophenyl)methyl]-2-[4-cyclohexyl-4-(1H-1,2,4-trazol-1-ylmethyl)-1-piperidinyl]-2-oxoethyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide

CAS Number

312637-48-2

PubChem ID

9938402

InChI Key

HLCHESOMJVGDSJ-LOYHVIPDSA-N

SMILES

O=[C@@]([C@H](NC([C@H]5CC(C=CC=C6)=C6CN5)=O)CC4=CC=C(Cl)C=C4)N1CCC(CN2N=CN=C2)(C3CCCCC3)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.89 10

Preparing Stock Solutions for THIQ

The following data is based on the product molecular weight 589.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.97 mL 84.87 mL 169.73 mL
0.5 mM 3.39 mL 16.97 mL 33.95 mL
1 mM 1.70 mL 8.49 mL 16.97 mL
5 mM 0.34 mL 1.70 mL 3.39 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 22 publications citing the usage of this product.

Product Documents for THIQ

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for THIQ

For research use only

Customer Reviews for THIQ (1)

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  • THIQ treatment increase social interactions
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 01/11/2019
    Recently, we demonstrated that the deletion of the NFKB1 gene, which encodes the p50 NF-kappa B subunit, causes impairment in social behaviours, with reductions in social interactions in mice. In this work, we tested the acute effects of THIQ, a selective melanocortin 4 receptor (MC4R) agonist. THIQ treatment increased social interactions both in wild type and p50-/- mice. In particular, after treatment with THIQ, p50-/- mice showed a prosocial behaviour analogous to that of basal WT mice.

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