Torin 2

Tocris Bioscience | Catalog # 4248

Potent and selective mTOR inhibitor
Tocris Bioscience

Key Product Details

Description

Potent and selective mTOR inhibitor
View all mTOR Inhibitors »

Product Description

Torin 2 is a potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively). Activates autophagy. Orally available.

Licensing Information

Sold under license from Whitehead Institute for Biomedical Research.

Product Specifications for Torin 2

Molecular Weight

432.40

Formula

C24H15F3N4O

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one

CAS Number

1223001-51-1

PubChem ID

51358113

InChI Key

GUXXEUUYCAYESJ-UHFFFAOYSA-N

SMILES

O=C(C=C3)N(C5=CC=CC(C(F)(F)F)=C5)C2=C3C=NC1=CC=C(C4=CC=C(N)N=C4)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.65 20

Preparing Stock Solutions for Torin 2

The following data is based on the product molecular weight 432.40.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.56 mL 57.82 mL 115.63 mL
1 mM 2.31 mL 11.56 mL 23.13 mL
2 mM 1.16 mL 5.78 mL 11.56 mL
10 mM 0.23 mL 1.16 mL 2.31 mL

Calculators

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Product Documents for Torin 2

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Torin 2

For research use only

Related Research Areas

Autophagy

Customer Reviews for Torin 2 (1)

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  • Torin 2 treatment
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: HPAF
    Verified Customer | Posted 03/21/2020
    100 nM for 1 hour
    Torin 2 4248

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