U 73122

Tocris Bioscience | Catalog # 1268

Phospholipase C inhibitor
Tocris Bioscience

Key Product Details

Description

Phospholipase C inhibitor
View all Phospholipase Inhibitors »

Product Description

U 73122 is a phospholipase C inhibitor. Inhibits agonist-induced platelet aggregation with IC50 values of 1-5 μM. Potently inhibits human polymorphonuclear neutrophil adhesion on biological surfaces (IC50 < 50 nM) and exhibits antinociceptive activity in vivo. Also activates TRPM4 and inhibits TRPM3 channels.

Negative Control also available.

Licensing Information

Sold with the permission of Pharmacia

Product Specifications for U 73122

Molecular Weight

464.65

Formula

C29H40N2O3

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione

CAS Number

112648-68-7

PubChem ID

104794

InChI Key

LUFAORPFSVMJIW-ZRJUGLEFSA-N

SMILES

[H][C@]23[C@@]([C@]([H])(CC[C@@H]4NCCCCCCN5C(C=CC5=O)=O)[C@]4(C)CC3)([H])CCC1=CC(OC)=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Please refer to these solubility guidelines for U 73122 (Cat. No. 1268).

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 557 publications citing the usage of this product.

Product Documents for U 73122

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for U 73122

For research use only

Related Research Areas

Bioactive Lipids and Receptors

Customer Reviews for U 73122 (3)

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  • Great product.
    Name: Mohammad Alqudah
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Smooth muscle
    Verified Customer | Posted 10/19/2022
    Great product. Used 10 uM to inhibit ACh-induced contraction in an organ bath of smooth muscle strips.
    U 73122 1268
  • great product
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Hippocampal neuron
    Verified Customer | Posted 03/26/2020
    100 μM treat 45min
    U 73122 1268
  • used this drug as an inhibitor
    Name: Eric Wang
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: macrophages
    Verified Customer | Posted 10/05/2017
    Pretreat mouse macrophage cells with this inhibitor prior to the bacterial stimulation.
    U 73122 1268

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