U 73343

Key Product Details

Product Description

U 73343 is an analog of U 73122; can be used as a negative control. Inhibits Panx1 currents in HEK cells. Also inhibits vasopressin- and GTPγS-induced Ca²⁺ influx in hepatocytes.

Active Analog also available.

Product Specifications for U 73343

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for U 73343

The following data is based on the product molecular weight 466.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.43 mL	107.14 mL	214.29 mL
0.5 mM	4.29 mL	21.43 mL	42.86 mL
1 mM	2.14 mL	10.71 mL	21.43 mL
5 mM	0.43 mL	2.14 mL	4.29 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 83 publications citing the usage of this product.

• Berven and Barritt Evidence obtained using single hepatocytes for inhibition by the phospholipase C inhibitor U73122 of store-operated Ca²⁺ inflow. Biochem.Pharmacol. 1995 PMID: 7763279
• Kataoka Activation of P2X₇ receptors induces CCL3 production in microglial cells through transcription factor NFAT. J.Neurochem. 2009 PMID: 19014371
• Ma Pharmacological characterization of pannexin-1 currents expressed in mammalian cells. J.Pharmacol.Exp.Ther. 2009 PMID: 19023039
• Muto The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell. J.Pharmacol.Exp.Ther. 1997 PMID: 9316850

Product Documents for U 73343