UK 5099

Key Product Details

Product Description

UK 5099 is an inhibitor of plasma membrane monocarboxylate transporters (MCTs) and the mitochondrial pyruvate carrier (MPC).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for UK 5099

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for UK 5099

The following data is based on the product molecular weight 288.30.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.47 mL	17.34 mL	34.69 mL
5 mM	0.69 mL	3.47 mL	6.94 mL
10 mM	0.35 mL	1.73 mL	3.47 mL
50 mM	0.07 mL	0.35 mL	0.69 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 37 publications citing the usage of this product.

• Hildyard Identification of the mitochondrial pyruvate carrier in Saccharomyces cerevisiae. Biochem.J. 2003 PMID: 12887330
• Hinoi A molecular mechanism of pyruvate protection against cytotoxicity of reactive oxygen species in osteoblasts. Mol.Pharmacol. 2006 PMID: 16766717
• Wiemer The inhibition of pyruvate transport across the plasma membrane of the bloodstream form of Trypanosoma brucei and its metabolic implications. Biochem.J. 1995 PMID: 8526859

Product Documents for UK 5099