7 results for "Monocarboxylate Transporter Inhibitors" in 产品
Monocarboxylate Transporter Inhibitors
There are 14 members of the solute carrier 16 (SLC16) gene family, four of which (SLC16A1, SLC16A3, SLC16A7 and SLC16A8) encode monocarboxylate transporters; MCT1, MCT4*, MCT2 and MCT3* respectively. MCTs have been shown to transport short-chain monocarboxylates such as L-lactate, ketone bodies and pyruvate across the plasma membrane of mammalian cells. MCTs have 12 transmembrane domains (TMDs) which consist of an intracellular N- and C-terminal and a large intracellular loop between TMDs 6 and ...
MCT inhibitor; also inhibits mitochondrial pyruvate carrier
| Chemical Name: | 2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid |
| Purity: | ≥98% |
MCT1 and MCT2 inhibitor; inhibits glycolysis in cancer cells
| Chemical Name: | 6-[(3,5-Dimethyl-1H-pyrazol-4-yl)methyl]-5-[[(4S)-4-hydroxy-2-isoxazolidinyl]carbonyl]-3-methyl-1-(2-methylpropyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione |
| Purity: | ≥98% |
Potent MCT1 inhibitor
| Chemical Name: | 2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one |
| Purity: | ≥98% |
MCT1 inhibitor; also inhibits hexokinase II
| Chemical Name: | 3-Bromo-2-oxopropanoic acid |
MCT inhibitor; decreases glycoloysis
| Chemical Name: | 2-Cyano-3-(4-hydroxyphenyl)-2-propenoic acid |
| Purity: | ≥98% |
MCT1 inhibitor
| Chemical Name: | 5-[[(3R)-3-Hydroxy-1-pyrrolidinyl]carbonyl]-3-methyl-1-(2-methylpropyl)-6-(4-quinolinylmethyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione |
| Purity: | ≥98% |
Potent and selective monocarboxylate transporter 4 (MCT4) inhibitor
| Chemical Name: | 5-[2-[5-Chloro-2-[[(5-ethoxy-8-quinolinyl)sulfonyl]amino]phenyl]ethynyl]-4-methoxy-2-pyridinecarboxylic acid |
| Purity: | ≥98% |
