Viral Dengue Virus 1 NS1 Alexa Fluor™ Plus 680‑conjugated Antibody

R&D Systems | Catalog # FAB9438AFP680

R&D Systems

Key Product Details

Species Reactivity

Viral

Applications

ELISA

Label

Alexa Fluor Plus 680 (Excitation = 687 nm, Emission = 704 nm)

Antibody Source

Monoclonal Mouse IgG2B Clone # 973602
View all Dengue Virus 1 NS1 Primary Antibodies »

Product Specifications

Specificity

Detects viral Dengue Virus 1 NS1 protein in direct ELISAs.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for Viral Dengue Virus 1 NS1 Alexa Fluor™ Plus 680‑conjugated Antibody

Application
Recommended Usage

ELISA

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Dengue Virus 1 NS1

Dengue virus type 1 non-structural protein 1 (DENV1 NS1)  is an approximately 50 kDa viral glycoprotein (1). Dengue viruses are mosquito-borne flaviviruses that exist in nature as four distinct serotypes (DENV1-4) (2). Dengue virus NS1 can be found associated with cell membranes, within cells and at the cell surface, or as secreted extracellular species. The secreted form of NS1 is known to be hexameric (1). Within cells, NS1 plays a significant role in virus replication and has been shown to co-localize with dsRNA and other components of viral replication complexes in viral-induced vesicle packets (1,3). Cell surface-associated and secreted NS1 are profoundly immunogenic, and both the protein itself and the antibodies it elicits have been shown to contribute to either protection or pathogenesis and innate immune evasion (1, 3). Mature DENV1 NS1 contains 352 amino acids (aa) and consists of 2 conserved N-glycosylation sites and 12 invariant cysteine residues that form six intramolecular disulfide bonds (3).Mature DENV1 NS1 shares 73%, 80%, and 69% aa sequence identity with DENV2, DENV3, and DENV4 NS1, respectively.

References

    1. Muller, D. et al. (2012) J. Gen. Virol. 93:771.
    2. VanBlargan, L.A. et al. (2013) PLoS Pathog. 9:e1003761.
    3. Flamand, M. et al. (1999) J. Virol. 73:6104.

Long Name

Dengue Virus 1 Nauru/West Pac/1974 Polyprotein

Alternate Names

DEN-1, Dengue virus Serotype 1, Dengue virus Type 1, DENV1, DENV1-NS1

Entrez Gene IDs

5075725 (Viral)

Gene Symbol

POLY

UniProt

P17763

Additional Dengue Virus 1 NS1 Products

Product Documents for Viral Dengue Virus 1 NS1 Alexa Fluor™ Plus 680‑conjugated Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Viral Dengue Virus 1 NS1 Alexa Fluor™ Plus 680‑conjugated Antibody


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

Related Research Areas

Infectious Diseases

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