VU 0134992

Key Product Details

Product Description

VU 0134992 is a K_ir4.1 potassium channel blocker (IC₅₀ = 0.97 μM). Displays 10-fold selectivity for K_ir4.1 over K_ir4.1/5.1 concatemeric channels and >30-fold selectivity over K_ir1.1, 2.1 and 2.2. Increases urine output and urinary Na⁺ and K⁺ excretion in volume-loaded rats.

Product Specifications for VU 0134992

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for VU 0134992

The following data is based on the product molecular weight 411.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.43 mL	12.15 mL	24.31 mL
5 mM	0.49 mL	2.43 mL	4.86 mL
10 mM	0.24 mL	1.22 mL	2.43 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Kharade Discovery, characterization, and effects on renal fluid and electrolyte excretion of the K_ir4.1 potassium channel pore blocker, VU0134992. Mol.Pharmacol. 2018 PMID: 29895592

Product Documents for VU 0134992