VU 591 hydrochloride

Tocris Bioscience | Catalog # 4197

Selective Kir1.1 (ROMK) inhibitor
Tocris Bioscience
Discontinued Product
4197 has been discontinued. View all Inward Rectifier Potassium Channel Blockers products.

Key Product Details

Description

Selective Kir1.1 (ROMK) inhibitor
View all Inward Rectifier Potassium Channel Blockers »

Product Description

VU 591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50 = 300 nM). Thought to block the intracellular pore of the Kir1.1 channel. Exhibits no effect on Kir7.1 at concentrations up to 10 μM; does not inhibit Kir2.1, Kir2.3 or Kir4.1. Displays similar potency to VU 590 (Cat. No. 3891).

Product Specifications for VU 591 hydrochloride

Molecular Weight

404.76

Formula

C16H12N6O5.HCl

Storage

Desiccate at RT

Purity

≥99% (HPLC)

Chemical Name

6-Nitro-2-[(6-nitro-1H-benzimidazol-2-yl)methoxymethyl]-1H-benzimidazole hydrochloride

CAS Number

1315380-70-1

PubChem ID

90488918

InChI Key

PXLOUHLPDHEXCC-UHFFFAOYSA-N

SMILES

O=[N+]([O-])C(C=C4)=CC2=C4N=C(N2)COCC1=NC(C=CC([N+]([O-])=O)=C3)=C3N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.83 100

Preparing Stock Solutions for VU 591 hydrochloride

The following data is based on the product molecular weight 404.76.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.47 mL 12.35 mL 24.71 mL
5 mM 0.49 mL 2.47 mL 4.94 mL
10 mM 0.25 mL 1.24 mL 2.47 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for VU 591 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for VU 591 hydrochloride

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for VU 591 hydrochloride (1)

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  • VU 591 works to block Inwardly Rectifying Potassium Channels on a few subfamilies
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 01/16/2019
    VU 591 works to block Inwardly Rectifying Potassium Channels on a few subfamilies.The blocking effect showed by VU 591 is variable on the different classes of Kir channels. Compared to VU 590 which was also used as a reference meausre its blocking action has been found to be on the lower side. Overall acts as a great measure for comparing blocking action.
    VU 591 hydrochloride 4197

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