WS 6

Key Product Details

Product Description

WS 6 induces growth and proliferation of cultured islet α and β cells in vitro (EC₅₀ = 0.28 μM at β cells). Inhibits growth of FLT3-ITD⁺ AML and K562 CML cells (IC₅₀ values are <0.24 nM and 40.48 nM, respectively). Reduces blood glucose in an animal model of type 1 diabetes. In combination with TTNPB (Cat. No. 0761) and 1-azakenpaullone, WS 6 induces and maintains murine totipotent stem cells. In an animal model of depression WS 6 induces dendrite complexity, enhances hippocampal neurogenesis, increases GABAergic neurons and GABA expression, and displays antidepressant and anxiolytic activity. WS 6 is predicted to be a receptor tyrosine kinase inhibitor.

Product Specifications for WS 6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for WS 6

The following data is based on the product molecular weight 568.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.76 mL	8.79 mL	17.59 mL
5 mM	0.35 mL	1.76 mL	3.52 mL
10 mM	0.18 mL	0.88 mL	1.76 mL
50 mM	0.04 mL	0.18 mL	0.35 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Bregante Efficacy and synergy of small molecule inhibitors targeting FLT3-ITD+ acute myeloid leukemia. Cancers (Basel) 2021 PMID: 34944800
• Shen Small-molecule inducer of β cell proliferation identified by high-throughput screening. J.Am.Chem.Soc. 2013 PMID: 23330637
• Zhang WS6 induces adult hippocampal neurogenesis in correlation to its antidepressant effect on the alleviation of depressive-like behaviors of rats. Neuroscience 2021 PMID: 34455011
• Menhaji-Klotz and Price Small molecules that promote regenerative repair for pancreatic and cardiovascular health. Bioorg.Med.Chem.Lett. 2015 PMID: 26508547
• Hu Induction of mouse totipotent stem cells by a defined chemical cocktail. Nature 2022 PMID: 35728625

Product Documents for WS 6