32 results for "Compounds for Stem Cell Proliferation and Renewal" in 产品
Compounds for Stem Cell Proliferation and Renewal
Maintaining stem cells in an undifferentiated state while in culture is important to ensure consistency and reproducibility among experiments. Traditionally, embryonic stem cells have been grown in culture using mouse embryonic fibroblasts as a feeder layer or using defined culture media. For some applications, the addition of small molecules to cu...
Selective ROCK inhibitor; inhibits ROCK1 (p160 ROCK) and ROCK2; stem cell freezing (cryopreservation) media component
| Alternate Names: | y27632,Y-27632 2HCl,ROCK inhibitor,ROCK1 inhibitor |
| Chemical Name: | trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride |
| Purity: | ≥98% |
Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7
| Chemical Name: | 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide |
| Purity: | ≥99% |
Y-27632 synthesized to cGMP guidelines
| Chemical Name: | trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride |
| Purity: | ≥99% |
SB 431542 synthesized to cGMP guidelines
| Chemical Name: | 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide |
| Purity: | ≥99% |
Selective inhibitor of TGF-βRI, ALK4 and ALK7
| Chemical Name: | 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide |
| Purity: | ≥98% |
Promotes HSCs expansion; increases HSCs engraftment; also endogenous prostaglandin
| Alternate Names: | PGE2 |
| Chemical Name: | (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1-oic acid |
| Purity: | ≥98% |
PORCN inhibitor; inhibits Wnt processing and secretion
| Chemical Name: | N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide |
| Purity: | ≥98% |
Selective inhibitor of p38 MAPK
| Alternate Names: | Adezmapimod |
| Chemical Name: | 4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine |
| Purity: | ≥98% |
Prototypical PI 3-kinase inhibitor; also inhibits other kinases
| Chemical Name: | 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride |
| Purity: | ≥99% |
MEK inhibitor
| Chemical Name: | 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one |
| Purity: | ≥98% |
Potent GSK-3 inhibitor; also inhibits cdks
| Alternate Names: | 6BIO |
| Chemical Name: | (2'Z,3'E)-6-Bromoindirubin-3'-oxime |
| Purity: | ≥98% |
FGFR1 and -3 inhibitor
| Chemical Name: | N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea |
| Purity: | ≥98% |
Cell culture supplement for improving stem cell survival
Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogenesis
| Chemical Name: | (3S)-N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-3,4-dihydro-6-methoxy-2H-1-benzopyran-3-carboxamide dihydrochloride |
| Purity: | ≥98% |
Heparin sulfate antagonist
| Chemical Name: | N,N'-Bis(4-amino-2-methyl-6-quinolinyl)urea dihydrochloride |
| Purity: | ≥98% |
Potent AMPK activator
| Chemical Name: | 6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile |
| Purity: | ≥98% |
Potent, selective GSK-3 inhibitor
| Chemical Name: | 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione |
| Purity: | ≥98% |
Potent pan-caspase inhibitor
| Chemical Name: | N-[2-(1,1-Dimethylethyl)phenyl]-2-oxoglycyl-N-[(1S)-1-(carboxymethyl)-2-oxo-3-(2,3,5,6-tetrafluorophenoxy)propyl]-L-alaninamide |
| Purity: | ≥98% |
Enhances survival of human ESCs following enzymatic dissociation
| Chemical Name: | N-(Cyclopropylmethyl)-4-[[4-(3,4-dihydro-6-hydroxy-1(2H)-quinolinyl)-2-pyrimidinyl]amino]benzenesulfonamide |
| Purity: | ≥98% |
Potent integrin inhibitor (αvβ3/αvβ6); also improves stem cell attachment in 3D cell culture scaffolds
| Purity: | ≥95% |
Notch signaling pathway activator; enhances the self-renewal capability of NSCs; active in vivo
| Chemical Name: | 5-(3-Methoxyphenoxy)-N2-[4-(1-methylethyl)phenyl]-2,4-quinazolinediamine hydrochloride |
| Purity: | ≥98% |
Induces growth and proliferation of pancreatic islet cells, murine totipotent stem cells, GABAergic neurons and hippocampal neurons
| Chemical Name: | 4-[[6-[(Cyclopropylcarbonyl)amino]-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzeneacetamide |
| Purity: | ≥98% |
DYRK1A/B inhibitor
| Chemical Name: | (1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone |
| Purity: | ≥98% |
Sterile-filtered 10 mM solution of Y-27632, selective ROCK inhibitor, pre-dissolved in water
| Chemical Name: | trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride |
| Purity: | ≥97% |
R-Spondin-1 substitute used to initiate small intestinal organoids
| Chemical Name: | 3,7-Dihydro-3,7-dimethyl-8-(2-quinolinylthio)-1H-purine-2,6-dione |
| Purity: | ≥98% |
