XPC Antibody

Novus Biologicals | Catalog # NB100-58801

Novus Biologicals
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Key Product Details

Validated by

Independent Antibodies

Species Reactivity

Validated:

Human

Cited:

Human

Predicted:

Canine (100%), Chimpanzee (100%), Monkey (100%), Orangutan (100%). Backed by our 100% Guarantee.

Applications

Validated:

Western Blot, Immunoprecipitation

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all XPC Primary Antibodies »

Product Specifications

Immunogen

The immunogen recognized by this antibody maps to a region between residue 890 and 940 of human xeroderma pigmentosum, complementation group C using the numbering given in entry NP_004619.2 (GeneID 7508).

Reactivity Notes

Gorilla (100%).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for XPC Antibody

Western Blot: XPC Antibody [NB100-58801]

Western Blot: XPC Antibody [NB100-58801]

Western Blot: XPC Antibody [NB100-58801] - Detection of Human XPC on HeLa whole cell lysate using NB100-58801. XPC was also immunoprecipitated by rabbit anti-XPC antibody NB100-58800.

Applications for XPC Antibody

Application
Recommended Usage

Immunoprecipitation

2-5 ug/mg lysate

Western Blot

1:2000-1:10000

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

TBS and 0.1% BSA

Preservative

0.09% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: XPC

Human XPC (Xeroderma pigmentosum group C) is a member of a family of proteins that has been shown to be involved in the repair of DNA via the nucleotide excision repair (NER) pathway. Specifically, XPC is believed to be a part of a heteromeric protein complex that is involved in the recognition of the DNA lesions during global genomic repair but not transcription-coupled repair. XPC may play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage processing enzymes. Defects in XPC are a cause of xeroderma pigmentosum complementation group C (XPC); also known as xeroderma pigmentosum III (XP3). XPC is a rare human autosomal recessive disease characterized by solar sensitivity, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities.

Alternate Names

complementation group C antibody, p125, RAD4, Xeroderma pigmentosum group C-complementing protein, xeroderma pigmentosum, complementation group C, XP3, XPCCDNA repair protein complementing XP-C cells

Entrez Gene IDs

7508 (Human)

Gene Symbol

XPC

UniProt

Q01831 (Human)

Additional XPC Products

Product Documents for XPC Antibody

Certificate of Analysis

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Product Specific Notices for XPC Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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