Weldable Workflow: Streamlining Cytokines for Closed-System CAR-T Manufacturing

Discover how GMP IL-7 and IL-15 cytokines supplied in weldable, single-use liquid bags can streamline CAR-T cell manufacturing while supporting fully closed workflows.

This study compares a closed-process workflow with a traditional open format, showing that closed process bags perform equivalently to traditional vials and bottles. Robust T cell expansion, viability, transduction efficiency, memory cell generation, and functional potency are maintained from research-scale to 1 liter manufacturing-scale closed processes. Additionally, the ProPak GMP cytokines alongside other closed process reagents benefit manufacturing workflows by removing manual reconstitution steps, reducing handling time, mitigating contamination risk, and decreasing cleanroom resource requirements.

Download the poster to learn how closed process reagents can help streamline the transition to scalable closed system cell therapy manufacturing.