3 results for "5-HT Transporter Compounds Small Molecules and Peptides" in 产品
5-HT Transporter Compounds Small Molecules and Peptides
5-HT transporters (serotonin transporters, SERT) are sodium- and chloride-dependent members of the solute carrier family 6 (SLC6) found widely distributed throughout the brain. They are responsible for re-uptake of 5-HT and undergo a conformational change to move one or more molecules per cycle.
Structural motifs include 12-TM domains, extracellular loops, cytoplasmic C- and N-termini, putative phosphorylation sites acting as potential targets for PKA and PKC and regions essential for 5-HT selective affinity. There is evidence to suggest that SERTs are linked to neuroticism, sexual behavior, alcoholism, clinical depression, hypertension and obsessive-compulsive disorder.
Endogenous 5-HT receptor agonist
| Alternate Names: | 5-Hydroxytryptamine,5-HT |
| Chemical Name: | 3-(2-Aminoethyl)-1H-indol-5-ol hydrochloride |
| Purity: | ≥98% |
Enantiomer of escitalopram oxalate (Cat. No. 1427)
| Chemical Name: | (-)-(R)-1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile oxalate |
| Purity: | ≥98% |
Inhibitor of SERT and nNOS interaction
| Chemical Name: | N-Acetyl-L-alanyl-L-valine methyl ester |
| Purity: | ≥98% |
