3 results for "Calcium-Sensing Receptor Modulators Small Molecules and Peptides" in 产品

Calcium-Sensing Receptor Modulators Small Molecules and Peptides

The calcium-sensing receptor (CaSR) is a G-protein-coupled receptor (GPCR) that senses extracellular Ca2+. The CaSR has wide tissue expression being found in the parathyroid gland, thyroid, kidney, intestine, skin, brain, heart, pancreas, bone and lung. First cloned from the bovine parathyroid gland in 1993, the primary role of CaSR activation is the inhibition of the release of parathyroid hormone (PTH).

CaSRs can also work independently of PTH. Local changes in extracellular Ca2+ regulate the ...

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Positive allosteric modulator of human calcium-sensing receptor (CaSR)

Chemical Name: 2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanamine hydrochloride
Purity: ≥98%
Positive allosteric modulator of human calcium-sensing receptor (CaSR)
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Negative allosteric modulator of calcium-sensing receptor (CaSR)

Chemical Name: 4-Chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-benzamide hydrochloride
Purity: ≥98%
Negative allosteric modulator of calcium-sensing receptor (CaSR)
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Biased allosteric modulator of calcium-sensing receptor (CaSR)

Chemical Name: α-(2,4-Dimethylphenyl)-α-methyl-2-benzothiazolemethanol
Purity: ≥98%
Biased allosteric modulator of calcium-sensing receptor (CaSR)
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