20 results for "Cell Cycle Inhibitors" in 产品

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Cell Cycle Inhibitors

Cell cycle inhibitors slow or stop cell cycle progression through various mechanisms. Cell cycle arrest can be induced at different stages, decreasing the rate of cell division and the number of actively cycling cells.

Pladienolide B

Catalog #: 6070
Citations (28)
Product Documents

mRNA splicing inhibitor; antitumor

Chemical Name: (4R,7R,8S,9E,11S,12S)-8-(Acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-hexadien-1-yl]-7,11-dimethyloxacyclododec-9-en-2-one
Purity: ≥95%
mRNA splicing inhibitor; antitumor

Methotrexate

Catalog #: 1230
Citations (15)
Product Documents

Cytotoxic agent

Chemical Name: N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Purity: ≥98%
Cytotoxic agent

XL 413 hydrochloride

Catalog #: 5493
Citations (3)
Product Documents

Potent and selective Cdc7 inhibitor

Alternate Names: BMS 863233
Chemical Name: 8-Chloro-2-(2S)-2-pyrrolidinylbenzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride
Purity: ≥98%
Potent and selective Cdc7 inhibitor

Roscovitine

Catalog #: 1332
Citations (46)
Product Documents

Cdk inhibitor

Alternate Names: CYC 202,Seliciclib
Chemical Name: (2R)-2-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol
Purity: ≥98%
Cdk inhibitor

YKL 5-124

Catalog #: 7157
Product Documents

Potent and selective CDK7 inhibitor; induces cell cycle arrest

Chemical Name: N-[(1S)-2-(Dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[[4-[(1-oxo-2-propen-1-yl)amino]benzoyl]amino]pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide
Purity: ≥95%
Potent and selective CDK7 inhibitor; induces cell cycle arrest

Narciclasine

Catalog #: 3715
Citations (8)
Product Documents

Stimulates RhoA activation; antiproliferative agent that slows cell cycle progression

Chemical Name: (2S,3R,4S,4aR)-3,4,4a,5-Tetrahydro-2,3,4,7-tetrahydroxy-(1,3)dioxolo(4,5-j)phenanthridin-6(2H)-one
Purity: ≥98%
Stimulates RhoA activation; antiproliferative agent that slows cell cycle progression

AZD 5438

Catalog #: 3968
Citations (13)
Product Documents

Cdk inhibitor; potently inhibits cdk1, 2, 5 and 9

Chemical Name: 4-[2-Methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine
Purity: ≥98%
Cdk inhibitor; potently inhibits cdk1, 2, 5 and 9

YC 1

Catalog #: 4307
Citations (10)
Product Documents

Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest

Chemical Name: 3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl indazole
Purity: ≥98%
Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest

10058-F4

Catalog #: 4406
(1)
Citations (25)
Product Documents

Inhibits c-Myc-Max dimerization

Chemical Name: 5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone
Purity: ≥98%
Inhibits c-Myc-Max dimerization

CPI 203

Catalog #: 5331
(1)
Citations (3)
Product Documents

BET bromodomain inhibitor; arrests cell cycle at G1 phase

Alternate Names: TEN 010
Chemical Name: (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide
Purity: ≥98%
BET bromodomain inhibitor; arrests cell cycle at G1 phase

CGP 60474

Catalog #: 5471
Citations (4)
Product Documents

Potent cdk inhibitor

Chemical Name: 3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol
Purity: ≥98%
Potent cdk inhibitor

WYE 687 dihydrochloride

Catalog #: 4282
Citations (3)
Product Documents

Potent and selective mTOR inhibitor

Chemical Name: N-[4-[4-(4-Morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-carbamic acid methyl ester dihydrochloride
Purity: ≥98%
Potent and selective mTOR inhibitor

Itraconazole

Catalog #: 5981
Citations (7)
Product Documents

SMO antagonist; acts at different binding site to cyclopamine (Cat No. 1623)

Chemical Name: 4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one
Purity: ≥98%
SMO antagonist; acts at different binding site to cyclopamine (Cat No. 1623)

FMF-04-159-2

Catalog #: 7158
Product Documents

Potent covalent CDK14 and CDK16 inhibitor; also inhibits other TAIRE kinase family members

Chemical Name: N-[1-[[3-[[(2E)-4-(Dimethylamino)-1-oxo-2-buten-1-yl]amino]phenyl]sulfonyl]-4-piperidinyl]-4-[(2,4,6- trichlorobenzoyl)amino]-1H-pyrazole-3-carboxamide
Purity: ≥98%
Potent covalent CDK14 and CDK16 inhibitor; also inhibits other TAIRE kinase family members

FMF-04-159-R

Catalog #: 7159
Product Documents

Potent CDK14 and CDK16 inhibitor; displays reversible inhibition of CDK14

Chemical Name: N-(1-((3-(4-(Dimethylamino)butanamido)phenyl)sulfonyl)piperidin-4-yl)-4-(2,4,6-trichlorobenzamido)-1H-pyrazole-3-carboxamide
Purity: ≥98%
Potent CDK14 and CDK16 inhibitor; displays reversible inhibition of CDK14

Verdinexor

Catalog #: 7569
Product Documents

Selective exportin-1 (XPO1/CRM1) inhibitor

Chemical Name: (2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyridinyl)hydrazide
Purity: ≥98%
Selective exportin-1 (XPO1/CRM1) inhibitor

ABT 263

Catalog #: 7680
(1)
Citations (5)
Product Documents

High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor

Chemical Name: 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide
Purity: ≥98%
High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor

Plitidepsin

Catalog #: 7416
Product Documents

Potent protein synthesis inhibitor

Alternate Names: Dehydrodidemnin B,DDB
Purity: ≥98%
Potent protein synthesis inhibitor

MR 24

Catalog #: 8122
Product Documents

Potent and selective MST3 kinase binding inhibitor

Chemical Name: 8-(4-Aminobutyl)-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(1,3-dihydroxypropan-2-ylamino)pyrido[2,3-d]pyrimidin-7-one trihydrochloride
Purity: ≥98%
Potent and selective MST3 kinase binding inhibitor

CX-4945

Catalog #: 8993
Product Documents

Potent and selective CK2α and CK2α' inhibitor. Also blocks CK2-dependent HIF-1α transcription, causes cell-cycle arrest, induces apoptosis in cancer cells and induces stem cell reprogramming

Alternate Names: Silmitasertib
Chemical Name: Sodium 5-[(3-Chlorophenyl)amino]benzo[c]-2,6-naphthyridine-8-carboxylate
Purity: ≥98%
Potent and selective CK2α and CK2α' inhibitor. Also blocks CK2-dependent HIF-1α transcription, causes cell-cycle arrest, induces apoptosis in cancer cells and induces stem cell reprogramming
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