16 results for "Chemokine CC Receptor Antagonists" in 产品
Chemokine CC Receptor Antagonists
Chemokine CC receptors (CCRs) predominantly recognize CC chemokines. CC chemokines are distinguished by having four conserved cysteines, although a small subgroup has six cysteines, with the first two cysteines being adjacent to one another. There are 10 chemokine CC receptors, with each one having a distinct chemokine and leukocyte specificity.
CC chemokines have a key role in the recruitment of monocytes and macrophages, cells types that are important in a number of chronic inflammatory ...
Highly selective CCR2 chemokine receptor antagonist
| Chemical Name: | 6-Methyl-1'-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one |
| Purity: | ≥98% |
Selective CCR5 antagonist
| Alternate Names: | UK-427857 |
| Chemical Name: | 4,4-Difluoro-N-{(1S)-3-[3-(3-isopropyl- 5-methyl-4H-1,2,4-triazol-4-yl)- 8-azabicyclo[3.2.1]oct-8-yl]-1- phenylpropyl}cyclohexanecarboxamide |
| Purity: | ≥98% |
Potent and selective CCR3 antagonist
| Chemical Name: | N-(1-Naphthalenylcarbonyl)-4-nitro-L-phenylalanine methyl ester |
| Purity: | ≥98% |
High affinity, potent CCR2 antagonist
| Chemical Name: | 2-[(Isopropylaminocarbonyl)amino]-N-[2-[[cis-2-[[4-(methylthio)benzoyl]amino]cyclohexyl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide |
| Purity: | ≥98% |
CCR2b chemokine receptor antagonist
| Chemical Name: | 1'-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one hydrochloride |
| Purity: | ≥98% |
Selective CCR1 antagonist
| Alternate Names: | VUF 2274 |
| Chemical Name: | 4-(4-Chlorophenyl)-4-hydroxy-α,α-diphenyl-1-piperidinepentanenitrile hydrochloride |
| Purity: | ≥98% |
Potent CCR1 chemokine receptor antagonist
| Chemical Name: | 1,4-cis-1-(1-Cycloocten-1-ylmethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-ethylpiperidinium iodide |
| Purity: | ≥98% |
Potent CCR1 and CCR3 antagonist
| Chemical Name: | 1,4-trans-1-(1-Cycloocten-1-ylmethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-ethylpiperidinium iodide |
| Purity: | ≥98% |
Potent, selective CCR1 antagonist
| Alternate Names: | ZK-811752 |
| Chemical Name: | (2R)-1-[[2-[(Aminocarbonyl)amino]-4-chlorophenoxy]acetyl]-4-[(4-fluorophenyl)methyl]-2-methylpiperazine |
| Purity: | ≥98% |
Potent CCR4 antagonist
| Chemical Name: | 2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine dihydrochloride |
| Purity: | ≥98% |
Potent and selective CCR3 antagonist
| Chemical Name: | N-Benzoyl-4-nitroaniline ethyl ester |
| Purity: | ≥98% |
Selective CCR2 antagonist
| Chemical Name: | N-[2-[[(3R)-1-[trans-4-Hydroxy-4-(6-methoxy-3-pyridinyl)cyclohexyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-benzamide dimethanesulfonate |
| Purity: | ≥98% |
Potent and selective CCR5 and CCR2 chemokine receptor antagonist
| Chemical Name: | N-[[4-[[[6,7-Dihydro-2-(4-methylphenyl)-5H-benzocyclohepten-8-yl]carbonyl]amino]phenyl]methyl]tetrahydro-N,N-dimethyl-2H-pyran-4-aminium chloride |
| Purity: | ≥98% |
Potent and selective CCR10 antagonist
| Chemical Name: | N-[(1R)-3-(2-Cyano-1H-pyrrol-1-yl)-1-[(4-methyl-1-piperidinyl)carbonyl]propyl]-1H-indole-4-sulfonamide |
| Purity: | ≥98% |
Potent and selective CCR4 antagonist
| Chemical Name: | 2,3-Dichloro-N-(3-methoxy-2-pyrazinyl)benzenesulfonamide |
| Purity: | ≥98% |
Potent CCR4 antagonist
| Chemical Name: | N-[[3-[[3-[[(5-Chloro-2-thienyl)sulfonyl]amino]-4-methoxy-1H-indazol-1-yl]methyl]phenyl]methyl]-2-hydroxy-2-methylpropanamide |
| Purity: | ≥98% |
