DHODH Inhibitors Small Molecules and Peptides

Dihydroorotate dehydrogenase (DHODH) EC 1.3.5.2 is a flavoenzyme responsible for the fourth step of de novo pyrimidine synthesis, required to produce DNA and RNA. In humans, DHODH is a monomeric protein found on the inner mitochondrial membrane, encoded by the DHODH gene.

DHODH is conserved across eukatyotes and prokaryotes, with proteins designated as Class 1 or Class 2 depending on sequence similarity, subcellular location and preference for substrate. Class 1 DHODH are soluble, cytosolic ...