GIP Receptor Antagonists

The GIP (gastric inhibitory polypeptide or glucose-dependent insulinotropic peptide) receptor is a member of the glucagon receptor family that also includes glucagon, GLP-1, GLP-2, secretin and GHRH receptors. The GIP receptor is involved in glucose homeostasis via potentiation of glucose-dependent insulin secretion from the pancreatic islet β-cells. It also inhibits gastric acid secretion. The tissue distribution of this receptor is broad, with high levels of expression in the islet β-cells. The human GIP receptor gene is localized on chromosome 19q13.3.