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Glucagon Receptor Modulators Small Molecules and Peptides

The glucagon receptor is a member of the glucagon receptor family that also includes GLP-1, GLP-2, secretin, GHRH and GIP receptors. The glucagon receptor regulates blood glucose levels via control of hepatic glycogenolysis and gluconeogenesis, and via regulation of insulin release from the β-cells of pancreatic islets.

The glucagon receptor is predominantly expressed in the pancreas, liver and kidneys, but is also found to a lesser extent in the heart, adipose tissue, spleen, thymus and adrenal glands. The human glucagon receptor gene is localized on chromosome 17q25.

Negative allosteric modulator of glucagon and GLP-1 receptors

Chemical Name: 4-[[(4-Cyclohexylphenyl)[[[3-(methylsulfonyl)phenyl]amino]carbonyl]amino]methyl]-N-2H-tetrazol-5-ylbenzamide
Purity: ≥98%
Negative allosteric modulator of glucagon and GLP-1 receptors
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