GPR171 Agonists Small Molecules and Peptides

GPR171, also known as platelet activating factor H963, is a member of the class A rhodopsin family of heterotrimeric G-protein coupled receptors. Until 2013, GPR171 was an orphan receptor, it is now known to be activated by the endogenous proSAAS-derived peptide BigLEN.

Expressed in the basolateral amygdala, and also in the hypothalamus where it co-localizes with its ligand, BigLEN, GPR171 shows high levels of similarity to P2Y receptors but exhibits different expression patterns and is not ...