GPR83 Agonist Small Molecules and Peptides

GPR83, encoded by the GPR83 gene, is a member of the Class A orphan receptor family of heterotrimeric G-protein coupled receptors and belongs to the NPY peptide receptor family. Formally an orphan receptor, GPR83 is now known to bind the endogenous proSAAS peptide PEN, an orexigenic neuropeptide.

GPR83 shows high abundance in the brain, particularly in the areas that regulates energy metabolism, including the amygdala, hypothalamus and brainstem. Expression of both GPR83 and PEN has also been ...