HIF Activators

Hypoxia Inducible Factors (HIFs) are transcription factors that are activated in response to decreased oxygen availability in the cellular environment. They influence cell metabolism, cell survival and angiogenesis to maintain biological homeostasis. The HIF family is made up of α subunits (HIF-1, HIF-2 and HIF-3) and a constitutively expressed β subunit (ARNT; also known as Aryl hydrocarbon Receptor Nuclear Translocator).

The best characterized hypoxia response pathway is mediated ...