Inflammasome Agonists Small Molecules and Peptides

A canonical inflammasome consists of a sensor molecule, which binds to caspase 1 via the adaptor protein ASC (apoptosis-associated speck-like protein). The exact composition of the inflammasome is determined by the type of activator. The most common sensor molecules are NOD-like receptors (NLRs); these include the subtypes NLRP1 (NOD-, LRR- and pyrin domain-containing 1), NLRP3, NLRP6, NLRP7, NLRP12, AND NLRC4 (NOD-, LRR- and CARD-containing 4; IPAF). Other sensor molecules include PYHIN, AIM2 ...